Mononuclear Oncogenesis: A 2010 Hypothesis in Light of Recent Research

Abstract

[No abstract available in the source PDF. First paragraph follows.] ncs.2026.00014. This perspective critically examines the hypothesis of “Mononuclear Oncogenesis” proposed by Shalin and Keskinov in their 2010 book. 1 The authors proposed that malignant stem cells originate from bone marrow-derived mononuclear cells (BMMNCs) that undergo genotypic and epigenetic al terations within isolated microcavities. We compared this hypothesis with academic research published since 2010, focusing on the evolving understanding of BMMNCs and monocytes in the development of solid tumors.