Volume 2, Issue 1 gathers six reviews spanning metabolism, oncology, nephrology and infectious disease. It opens with liver–bone crosstalk, detailing how hepatic signals orchestrate bone remodeling. The issue then covers endoscopic advances in early gastric signet ring cell carcinoma and immunotherapeutic strategies for pMMR/MSS metastatic colorectal cancer. Public health perspectives include tuberculosis care during the COVID-19 pandemic in India and Costus speciosus signaling pathways as a potential therapy against SARS-CoV-2. Finally, optimized immunosuppressive approaches in glomerular diseases are discussed. Together, the articles reflect the journal's mission of linking molecular insights with clinical and global health challenges.