Vol. 3 No. 1 (2025)

Volume 3, Issue 1 covers neurodegeneration, gastroenterology, ophthalmology and critical care medicine. It examines disruptions in adult neurogenesis as a mechanism underlying cognitive decline and neurodegenerative diseases, and explores the ROS/NLRP3 axis in autophagy regulation as a therapeutic target in inflammatory bowel disease. The issue addresses myopia through both a pathogenesis review and a comparative study of low-dose atropine, orthokeratology and combined treatments. An in silico approach investigates cadmium-induced GSK-3beta dysregulation in Alzheimer's disease progression, while another article reviews epidemiology and management strategies for sepsis-associated acute kidney injury. Together, the articles span molecular mechanisms to clinical interventions across multiple organ systems.