Volume 4, Issue 1 brings together perspectives, mini reviews and original research across oncology, neurology, cardiology and nephrology. A perspective discusses GnT-V inhibition as a strategy to curb cancer metastasis, while another revisits the mononuclear oncogenesis hypothesis in light of recent research. The issue reviews neurological manifestations of IgG4-related disease and current biomarker evidence in congenital heart disease. An original study examines quality of life and medication adherence among hemodialysis patients, linking clinical parameters with social support and spiritual needs. Together, the articles reflect the journal's broad scope spanning molecular hypotheses to patient-centered outcomes.