Volume 1, Issue 1 gathers four reviews linking retinal and neural biology to clinical eye care. It examines D-serine as an NMDA receptor co-agonist in normal visual signaling and retinal degeneration, and reviews bioscaffold strategies that support Schwann cell survival, migration and myelination for peripheral nerve repair. Another article explores how impaired crosstalk between autophagy and the ubiquitin-proteasome system may drive drusen formation, inflammation and retinal pigment epithelium dysfunction in age-related macular degeneration. The final review discusses the relationship between myopia and cataract, including shared risks, surgical planning and rehabilitation in highly myopic patients. Together, the issue bridges discovery and practice across retinal neuroscience, tissue engineering and ophthalmology.