Revolutionizing Vascular Health: Unveiling the Potential of MicroRNA Therapies in Peripheral Arterial Disease

Abstract

[No abstract available in the source PDF. First paragraph follows.] Sci 2024;2(2):112–120. doi: 10.61474/ncs.2024.00001. Introduction Peripheral arterial disease (PAD), a global public health concern, is increasingly prevalent and poses serious risks. It is characterized by reduced blood flow to the extremities, leading to complications beyond vascular insufficiency (Fig. 1). The disease is a major contributor to morbidity and mortality, with recent statistics indicating a rising trend in its prevalence, particularly among the aging population. The global prevalence of PAD has shown significant increases over the years, as described in the Global Burden of Disease Study 2019 database, a systematic analysis of 369 diseases and injuries in 204 countries and territories published in The Lancet in 2020.