Volume 3, Issue 4 spans neuro-oncology, ophthalmology, psychiatry and neurodegeneration. It reviews nanoparticle-assisted oncolytic virotherapy as an advancing strategy for brain cancer treatment and drug delivery. The issue explores macular subthreshold laser therapy with current concepts and clinical applications, and examines microglial synaptic pruning in the context of amygdala hyperconnectivity and memory impairment in post-traumatic stress disorder. Nutritional interventions for mental health are reviewed, and the astrocytic lactate shuttle is discussed as a therapeutic target in tauopathies. Together, the articles reflect innovative approaches to neurological and psychiatric disorders.