Vol. 2 No. 4 (2024)

Volume 2, Issue 4 brings together five articles at the intersection of neuroscience, pharmacology and genomics. It bridges psychiatry and neuroscience by examining brain complexity and neural circuit dysfunctions underlying anxiety, depression and schizophrenia. A comprehensive review covers the phytochemicals and therapeutic mechanisms of Catharanthus roseus, while a systems biology approach combined with deep neural networks is proposed for multi-molecule drug design in frontotemporal dementia. The issue also explores membrane lipid replacement as a strategy to restore mitochondrial function in aging and age-related conditions, and discusses the GONAD/i-GONAD technology as a novel in vivo genome editing platform for generating genome-edited large experimental animals. Together, the articles reflect innovative approaches to understanding and treating complex diseases.